The Curio Seller

They come and they go, at night, at dawn, settling down the great lizard just outside of town and pulling up the flesh-curtains to reveal the wares secreted within [Only some of the wares were secreted by the lizard through its esoteric glands, the others were just hidden normally]. They (mostly people say say) wear a thick, oily leather coat, strapped together, and huge boots and gloves, misshapen and probably not filled out within. Their face, is wooden, as is the rest of their head. A wooden mask of a smiling she-devil, strapped roughly to a wooden head. It sounded hollow when people threw stones at them at least.
They don't let this get them down. They merely travel from place to place, selling and trading for the misused and misbegotten detritus of history to people nearly as strange as they are.

The Curio Seller usually has 6 'slots' worth of wares for sale, and d4+1 curios.
3 of these slots are for 2d4-1 objects of slightly uncommon origin.
2 of these slots are for d4 objects of curious origin.
And 1 slot is open for a single object of truly special aspect.
You may also spend half an hour searching through the back rooms of the Curio Shop to try and find additional curios to purchase, finding d3-1 for each half hour spent searching.

The Curio Seller has 12 different wares it can sell:
1 - A scrap/fragment/whole spell.
2 - A pamphlet/notebook/codex written on Alchemy.
3 - A tome of uncommon/old/esoteric lore.
4 - A minor/major/extraordinary Work of Art.
5 - Phials of tincture/potions/elixirs
6 - A single crystal/gems/jewels of various colours.
7 - A map of the area/realm/land.
8 - A small/big/huge mirror.
9 - An initiate/journeyman/expert weapon.
10 - A piece of initiate/journeyman/expert scrimshaw.
11 - A small/medium/long totem charm.
12 - A bundle of uncommon/rare/vanishing herbs.

Where the wares have three words separated by slashes, the first word refers to uncommon objects, the second for curious objects, and third for special objects.

The Curio List
1 - A glass key of curious aspect, labelled "4" in an ancient tongue.
2 - The northern half of a star map showing strange stars.
3 - A vial of "Medusa Anti-Venom," stoppered with charred leather.
4 - A ring bearing ruby, within dances a tiny flame.
5 - A bundle of 5 golden feathers, purportedly the Thunderbird's.
6 - The supposed shin-bone of a Land-Whale, or perhaps a Land-Shark.
7 - A jar of liquid with 3 floating, jellied eyes. They follow you.
8 - A pouch of dust from the floor of the Cathedral of the Baptist.
9 - The deed to a castle you've never heard of, or can find on any map.
10 - The broken handle of a sword. Clutch it in sleep, and you dream of the blade.
11 - A pinch or two of ground unicorn horn in a silken bag.
12 - An arrow supposedly fired by the Master of the Wild Hunt. Still poisonous.
13 - The family tree of the 'Von Arngaults' emblazoned on a shield.
14 - A bottle of water blessed by the Gracious Saint Crane.
15 - A book with a pressed, scarlet flower, and a beautiful inscription (in Fae).
16 - A delicate mechanical butterfly, its wings inlaid with unmelting ice.
17 - Three exquisite silver stakes, wrapped in splendid cloth.
18 - A monocle with a cloudy jade lense, runes ring the bronze setting.
19 - A jar full of brittle, carved jet snakes, labelled; 'Burn'.
20 - A pot of particularly pungent ooze, labelled; 'Troll Musk.' Vile.
21 - A dusty bottle of... wine? Labelled; 'For the Banded Prince.'
22 - An ugly stone idol, it squats, leering, and it reeks of meat.
23 - A shred of mirror, though it reflects a strange library interior.
24 - A brass plate etched with burning, hateful symbols; a demon's name.
25 - A piece of bone, blackened and burned, inlaid with gold.
26 - A glass jar, sealed and full of golden liquid preserving a hand.
27 - A vial of blood, dressed in glittering runes and dried herbs.
28 - A shred of a white tree, it smells like tar or pitch.
29 - A locked, sandalwood box, it thumps rhythmically from within.
30 - A cameo depicting a noble-woman, inscribed in burning Infernal.
31 - A plain ebony ring, inscribed; 'This too, shall pass.'
32 - A dried and preserved heart, impaled cross-wise with two wooden nails.
33 - A golden ingot, wrapped in parchment, closed with a wax seal.
34 - A dry and dusty worm in a beautifully embroidered pocket.
35 - A tiny statuette of a praying saint, apparently life-sized.
36 - A scrap of cloth, embroidered; 'Drink of me, that I may drink of thee.'
37 - A shaman's staff, adorned with much bone, tied up with rough twine.
38 - A time-piece with many, many hands of inscrutable purpose.
39 - An urn depicting the 4 Divine Beasts of Daizuku.
40 - A map depicting a series of curious... canals? (Ley Lines)
41 - Half a book depicting many strange and wonderous works, incomplete.
42 - A sealed envelope, bearing the mark of an unknown house.
43 - An opal-adorned snuff box, hiding a key under a false bottom.
44 - A dried and leathery, imp-like corpse of a homunculus.
45 - A poultice of peculiarly pungent herbs, defies identification.
46 - A chain of alternating brass and silver links, ending with leering faces.
47 - A box of salt, engraved; 'For the last sins of Ninevah.'
48 - A shrunken, pickled head, eyes sewed shut, mouth nailed closed.
49 - A roughly humanoid statuette, wrapped in chains, engraved with curses.
50 - A golden apple, engraved; 'For the Fairest of All.'
51 - Lightning struck metal, unrecognisable, warped and twisted.
52 - Dark, dark glass, cloudy like smoke, coiling within, surprisingly cold.
53 - A series of rugged, black stone blocks, bearing runes, not quite dice.
54 - Half a brass pendent, engraved; '-urying a great fortune at the hi-'.
55 - An apparently marble, suspiciously warm, perfectly smooth egg.
56 - A wooden idol of twin, entwined snakes, wickedly sharp teeth.
57 - A halo of iridescent... glass? Crystal? Angelic, in theory.
58 - A key with human teeth, and a metal heart, which beats, improbably.
59 - A bag of thick, slightly yellow teeth, labelled; 'Do not Sow.'
60 - A glass jar, wax-sealed shut, full of roe-like ooze capsules.
61 - A set of 5 lapis lazuli and gold animal brooches, supposedly lucky.
62 - A small bottle of potent, sweet spirit. When over-imbibed, it induces long comas.
63 - A capsule of inordinately rotten... something. Not particularly sturdy.
64 - A pair of old, old hair pins, tarnished, glowing.
65 - An ancient... chart? Map? Only one or two familiar features.
66 - A set of gemstone needles in rainbow colours, and golden thread.
67 - A beautiful flower, carved from bone, clutching a ruby deep within.
68 - A code cipher, rings set in rings, and a strange central sigil.
69 - A withered and dried ring and little finger, glass nails, metal bones.
70 - A clay and silver ying-yang, bearing a solomonic symbol.
71 - A phial of saint's ashes, a particularly potent lucky charm.
72 - A finely wrought compass with a beautiful brass setting.
73 - 7 charcoal-like sticks that produce a heady smoke when broken.
74 - A charm made of the hair of priests, a defence against demons.
75 - A candle of mysterious origins, its smoke induces powerful dreams.
76 - A crude obsidian knight, with colourful feathers bound to it.
77 - A tiny, still articulated wolf-skeleton, the size of a large rat.
78 - A book of prayers, a couple of spells scribbled in the margins.
79 - A beautiful bottle of rust-red wine, apparently a Djinn vintage.
80 - A mask of pale wood with stone teeth and glass eyes.
81 - A pair of old, dull Obols like stormy skies. Offerings for the dead.
82 - A glass animal filled with a thick red syrup, and no apparent opening.
83 - A lump of carved coal, set in an ornate chain. Improbably cold.
84 - A butterfly brooch, though only one of its four settings is filled.
85 - A pendent of an eye, sometimes it blinks, sometimes it weeps.
86 - A book of wilfully blank pages, a gnashing maw on the cover.
87 - A claw hammer, carved entirely of odd blue crystal. Strangely sticky.
88 - An old, old wooden box, roughly carved, holding only dirt.
89 - A scrap of tapestry, depicting a man, a richly ringed hand held aloft.
90 - A small cat statuette, one eye closed, glass claws and teeth.
91 - An exquisite ivory drinking horn, meandered by arcane runes.
92 - An ocarina, apparently sewn together from various leathers.
93 - A somewhat abstract stone bird, talons clenching... something.
94 - A once shattered jade tea-cup, cracks filled in with gold.
95 - A curse-tablet of baked clay, and space for a name.
96 - A penance stone, unnamed, unworn, unbloodied, still potent
97 - A scarf depicting a mountain topped with a great, smoking mirror.
98 - An incense burner shaped like a wolf swallowing a bird.
99 - A blocky, abstract bronze mask of a horned demon, tongue lolling crazily.
100 - A golden disk, ringed with bone and wood, depicting a bleeding sun.

Alchemy

The Grand Arts of Alchemy

According to Alchemists, all that is can be divided eventually down into 8 Dominions, through which all matter can be categorised and translated, eventually, through secret and perilous arts. The path of Alchemy is much the same as our modern understanding of science, only mixed in with perhaps equal parts magic, philosophy, and luck. The most dedicated Alchemists end up changes and warped by their secret knowledges, and those that seek the Magnum Opera, are the most twisted of all.

The Dominions of Alchemy

Metal - Base
The name of all base things that are inorganic. Characterised by heaviness, denseness, darkness. The Alchemist with the Knowledge of the Metal domain practices in many ways the most famous of Alchemical practices, the translation of base metals into gold, silver, and other precious metals. Unknown to most, these practices are common, even basic, procedures. The trick is to make it economical. The more immediately useful aspects of the Metallic Alchemist's arts, are the imbibing of properties into metals, such as conductivity to magic, or resistance to the same for example.
Crystal - High
The name of all grand things that bear not the stains of life or the indignities of formlessness. Characterised by beauty, delicateness, lightness. Crystal has many esoteric and unintuitive properties to the uninitiated. Conduction of energies beyond the mortal mind, the focusing and refining of magic, the restructuring of other materials; all these are the realm of the Crystalline Alchemist who knows when to grind, or grow, when to nurture large matrices, or rush small ones.
Liquid - Base
The beginnings of formlessness, labile boundaries and permeable to many manners of things. The most common uses of Liquid Alchemy are the most widely practised; the creation of healing drafts, and other such potions of varying effects. They can range from simple dyes, to deathly concoctions that reek of chemicals. Putties and oils also fall within the Liquid Alchemist's remit.
Aetheric - High
The ending of formlessness; so far removed from being that anything can pass through it. Yet even so it bears many effects on the realms of what is, and is necessary for life (as far as is known), and must in some small way unknown to Natural Philosophy be made up of infinitesimal matter. The Aetherically gifted Alchemist can whip up storms in bottles, or create potent vapours, or remove them entirely from an area.
Flora - Base
The unthinking mode of living flesh and organic compounds. The Alchemist who practices the lore of Floral Alchemy can grow and thus create living things with properties and uses of their desire. Remedies, poisons, drugs, pigments, food-stuffs, all these and more are among the remit of the Floral Alchemist. The most knowledgable Floral Alchemist can even reach past the limits of plants and delve into the secrets of other organic matrices, the powers of soils, certain stones, fabrics even.
Fauna - High
The thinking mode of what lives, which might even give rise eventually to the self, a much sought after goal of Alchemy. The Alchemist versed in Faunal methods can reshape flesh to suit and serve; they can change its material, adapt its purposes, enhance or dull its senses. They can even create small servants to perform small tasks.
Energetic - Heresy
The heresy of the Energetic Alchemist is that they do not deal in matter and being and modes of refinement. The Energetic Alchemist deals in the realm beyond matter to touch on the realms of energy, the base actions of thought, the movement behind the moving. Their currency is lightning, their creations brass and metals in intricate patterns to achieve the impossible.

Alchemical Actions

The Alchemy Roll

In general, most actions you can perform with your secret arts requires either a recipe, or an Alchemy roll. Alchemy rolls consist of you trying to roll beneath your Alchemy skill ranks on a d6, with a number of modifiers attached to the roll. At the DM's discretion, if the task is particularly easy or difficult, the size of the dice can be changed to better represent the challenge at hand.   

Basic Alchemy

This action allows you to turn a material into another material of the same dominion. You need only pass an Alchemy check to do so.

Ascension/Debasement

This action allows you to turn a material of a base dominion into a material of its high dominion, or vice versa. Ascending a material gives a penalty of -1 to your alchemy roll.

Translation

This action allows you to turn a material of a base dominion into a material of another base Dominion.

Infusion/Cancellation

This action allows you to add (infuse) or remove (cancel) a property to/from a material. Ascending a material gives a penalty of -1 to your alchemy roll. You may not infuse additional properties to a material that has more properties than you have ranks in Alchemy.
[In this case, properties refer to special and unusual properties of materials, even those that are not common to their dominion. For example, the healing effects of a potion are a property, the poisonousness of a venom is a property, and the reflectiveness of a metal to name a few.] 

Combination/Separation

This action allows you to combine two materials of the same dominion into a material with both of its component material's properties, or separate a material with at least two properties into two materials of the same dominion with the properties of the original material split between them as the alchemist sees fit. Ascending a material gives a penalty of -1 to your alchemy roll.

Recipe

You can of course bypass all rolls if you posses a recipe, as long as you fulfil the requirement of the recipe. You can learn recipes that you posses in the same way as wizards learn new spells. You can create recipes by passing an Alchemy roll, at your DM's discretion.

Archetypes of Alchemists

Basic
Dealing with lower level materials grants the Basic Alchemist a wide range of knowledge and applicable methods. Note however, that basic does not refer to the techniques and capabilities of the Alchemist, merely the states of matter with which they work. They manoeuvre the modes of matter with expert precision, and restructure, refine, and combine with ease. They seek the Universal Panacea, with which all impurity and ill-humour can be destroyed.
Specialist Dominions: Metal, Flora, Liquid
Magnum Opus: The Universal Panacea
Suggested Recipes: Healing drafts, alchemist's fire, oil of slipperiness, glue bombs.
First Negation: Skin-deep blemishes remove themselves from you. You skin is perfect and smooth.
Second Negation: All features on you become perfectly arranged, mathematically so. Its somewhat unnerving.

Biological
With a focus one the modes of matter that live, Biological Alchemists can sometimes come across as playing at god, rearranging the stuff of life in the means that suit them. They rearrange flesh as easily as speaking, they nurture and cultivate life at a whim. Life is but another tool in their arsenal, and all manner of servants follow them, fulfilling maddeningly specific purposes.
Specialist Dominions: Flora, Fauna
Magnum Opus: True Homunculus
Suggested Recipes: Temporary animal aspect potions, draft of water-breathing, tangle-weed bombs.
First Negation: Your blood changes colour, and your flesh changes texture. The changes are random, and change every few days.
Second Negation: Plant-like materials sprout from odd places on your skin, and your flesh is slightly spongey to the touch.

Aethereal
The Aethereal Alchemists
Specialist Dominions: Liquid, Aetheric
Magnum Opus: Breath of Life
Suggested Recipes: Smoke grenades, vapours of vigour, sleeping drafts, potent acids.
First Negation: You are always buffeted by a unseen, unfelt wind which only affects you.
Second Negation: You hover slightly above the ground. If you breath hard, it can be heard like wind in a canyon.

Empirical
Empirical Alchemists
Specialist Dominions: Metal, Crystal
Magnum Opus: Perfect Translation [The Fundament Forge]
Suggested Recipes: Specially treated metals, artificial arcanite crystal, conduction rods.
First Negation: Your eyes become glassy, your hair becomes metallic and rigid, your nails are iron.
Second Negation: Your bones become hard and crystalline within you, in some places they jut awkwardly (though painlessly) from your body.

Abstract
Quite what it really is that the Abstract Alchemists really do is up for much debate.
Specialist Dominions: Crystal, Fauna, Aetheric
Magnum Opus: The Philosopher's Stone
Suggested Recipes: Drafts of Elemental Immunity, Draft of Mind Erasure, Living Crystals
First Negation: Solid matter in your body becomes subtly gem-like, your blood runs thin.
Second Negation: Your blood is totally gaseous now, bleeding is more like letting air from a balloon. You breath reeks of ozone.

Heretical/Energetic
Dangerous and deviant, Energetic Alchemists must keep their heresies down in the darkness away from prying eyes.
Specialist Dominions: None
Magnum Opus: The Machine Mind
Suggested Recipes: Lightning in a Bottle, Stun Mines, Trip-Wire Bombs, Kinetic Absorbers.
First Negation: Small jolts of light dash along your veins, your teeth spark sometimes when they touch.
Second Negation: Your joints lose some of their plasticity, your muscles curl like plastic tubing beneath your skin.
Conductions: Instead of Specialised Dominions, Conductions allow you to generate energy from Dominions with an Alchemy Roll. Energy is key to following and powering Energetic recipes. You may not Conduct energy from areas you do not have a Conduction for, though when you choose Conductions, you can choose any Dominion for it.

The Alchemical Path - The Easier Way

If you want a simpler way to progress this skill, then just follow the instructions below.
A character gains the following benefits at the following ranks of Alchemy.

1 rank: The character can perform Alchemy Rolls, and chooses their Archetype.
2 ranks: The character chooses one of the Dominions in their Archetype's areas to become a Specialised Dominion. They show the signs of their First Negation. They gain their Archtype's trait.
Basic Trait: +1 to Translation Rolls
Biological Trait: +1 to Infusion Rolls
Aethereal Trait: +1 to Combination Rolls
Empirical Trait: +1 to Rolls to generate Money
Abstract Trait: +1 to Ascension Rolls
Heretical/Energetic Trait: Conductions rather than Specialisations
4 Ranks: The character chooses another Dominion in their Archetype's areas to become another Specialised Dominion. They show the signs of their Second Negation.
Maximum Ranks: The character can now begin work on their Archetype's Magnum Opus. Should they ever complete it, they show the signs of their Final Negation.

The Alchemical Sephirot - The Harder Way

With each rank gained in the Alchemy Skill, the Character gains a new space on the Sephirot, beginning first with Kingdom at the first rank. Each space can only be chosen if the character already posses a space that is connected to it. Thus, the second space chose must always be Foundation, and after that, the third space can be Splendour, Eternity, or Beauty.
Once the maximum number of ranks have been attained, new spaces on the Sephirot can be gained by expenditure of time and resources equal to those needed to have attained the maximum rank, and by achieving something within the field of Alchemy that has never been achieved before.
[This will probably require some amount of DM discretion. In general, the projects to acquire further spaces on the Sephirot should be grand in scope, and novel in some regard at least. Err on the side of generosity as long as they aren't phoning it in.]  
 

Kingdom

This is gained when you take your first rank in Alchemy. With it, you gain basic access to Alchemical processes and knowledge.

Foundation

This is gained when you take your second rank in Alchemy. With it, you gain a Dominion Specialisation from on your chosen Archetype's areas.

Splendour

You may purchase this Sephirot area when you gain a new rank. With it, you suffer no penalty to Ascension rolls.

Eternity

You may purchase this Sephirot area when you gain a new rank. With it, you suffer no penalty to Translation rolls.

Beauty

You may purchase this Sephirot area when you gain a new rank. With it, you gain an additional Dominion specialisation.

Judgement

You may purchase this Sephirot area when you gain a new rank. With it, you suffer no penalty to Combination and Separation rolls.

Kindness

You may purchase this Sephirot area when you gain a new rank. With it, you suffer no penalty to Infusion and Cancellation rolls.

Knowledge

You may purchase this Sephirot area when you gain a new rank. With it, you gain +1 to rolls involving your Dominons of Specialisation.

Understanding

You may purchase this Sephirot area when you gain a new rank. With it, you gain +1 to rolls concerning Dominions adjacent to your areas of Specialisation.

Wisdom

You may purchase this Sephirot area when you gain a new rank. With it, you gain +1 to rolls concerning Dominions

Crown

You may purchase this Sephirot area when you gain a new rank, as long as you have all three of Knowledge, Understanding, and Wisdom. With Crown, you can begin the long journey to the creation of your Specialisation's Magnum Opus.

The Magnum Opera

The process of creating the Magnum Opera has never been documented in history, though the results of them have popped up here and there in history, presumably created by non-human hands through their mysterious magics and powers. The ultimate dream of every Alchemist is the creation of their Magnum Opus. Some have come close. By the grace of gods, perhaps you will be the first.

Once either the maximum ranks in Alchemy has been gained (if using the easier way) or the Crown has been achieved (is using the harder way), the final project can be put into motion. In no particular order, the Alchemist must succeed on at least 3 Alchemy rolls on a d10 to determine the process of creation. They must obtain the Key Reagent for the creation of the Magnum Opus (which is specific to each Opera) which probably is a great quest in and of itself. Optionally, the Alchemist can also gather up a Catalyst for the reaction, which is not necessary, but makes the final process easier. To create the Magnum Opus consumes the Key Reagent, and requires the Alchemist pass an Alchemy roll on a d12, which can be rolled twice and the better result taken if a sufficient Catalyst is present and consumed. If the roll is passed, the Alchemist must make the Sacrifice, they show the signs of their Final Negation, and their, glistening, gleaming, is the Magnum Opus. Nothing will ever be the same.

The Universal Panacea

Effect: Instant return to maximum hit points, curing of all negative effects, -1 maximum hit points permanently.

Key Reagent: The Roots of the Oolean Poppy Plants

Catalyst: Flesh untouched by Sickness

The Sacrifice: You automatically fail saving throws against poison. 

Final Negation: All blemishes are gone from your body, all deviations smoothed out. You are the perfect (unnervingly and inhumanly so) example of your kind.

The Breath of Life
Effect: You are immune to all the deleterious effects caused by your environment. Inasmuch as they will not kill you, at least. Discomfort and pain are yet your travelling companions.
Key Reagent: An Angel's (or other such space-faring creature's) Lungs
Catalyst: Corpses of Creatures with Elemental Immunities
The Sacrifice: Loss of Homeostasis [you become terribly vulnerable to environmental dangers]
Final Negation: You are always cold, your breath comes out in harsh gasps, dew forms on you at all hours.

The True Homunculus
Effect: If your body is brought back to your Homunculus within a day of your death, you can return from death in a new body.
Key Reagent: Clay of the Garden of Childhood (or wherever mankind was born)
Catalyst: Doppelganger Corpses
The Sacrifice: You automatically fail saving throws against System Shock
Final Negation: Your flesh is sickly and pallid, barely holding itself together. Your mind, however, is sharp as razors, and easily (and harmlessly) removed from your ailing body.

Perfect Translation - The Fundament Forge
Effect: You can create whatever you want, no rolls necessary, gram for gram.
Key Reagent: A Tongue of the Immortal Flame
Catalyst: Vast, VAST amounts of Gold
The Sacrifice: You have the Midas Touch
Final Negation: Your skin is gold; your eyes, gemstones; your blood, a flow of rubies.

The Philosopher's Stone
Effect: You will never die of age, or age related concerns. You maximum hit points cannot be decreased.
Key Reagent: A Heart of an Immortal
Catalyst: The Blood of Many Races
The Sacrifice: Addiction to the Elixir of Life (instant, no save possible)
Final Negation: Your breath is a hurricane within you, your flesh studded with gleaming crystal, your remaining meat a wild kaleidoscope of colours.

The Machine Mind
Effect: Oh shit, its a sentient AI. Fuck. What have you done?
Key Reagent: The Recursive Connection Theory (said to be held by the Djinn Technocrats)
Catalyst: Copious amounts of Lightning
The Sacrifice: You automatically fail saving throws against Devices
Final Negation: Your veins are wires; your meat tubes, metal pipes; your flesh nets, gauze.

[Final Designer Notes]
This is designed for a system like LotFP, where skills are ranked from 0 to 6.